Downstream Processing Market Size To Grow USD 87.81 Bn 2032

The downstream processing market size was valued at USD 24 billion in 2022 and is estimated to reach around USD 87.81 billion by 2032, growing at a CAGR of 13.9% from 2023 to 2032.

Downstream Processing Market Size 2021 to 2030

Table of Contents

Key Takeaway

North America dominated the global market with a major market share of 36% in 2022.
Asia-Pacific is expected to expand at the fastest CAGR between 2023 and 2032.
By Application, the antibiotic production segment generated more than 44% of revenue share of 34% in 2022.
By Technique, the monoclonal antibody medication segment contributed more than 42% of revenue share in 2022.
By Product, the thalassemia segment has held the biggest revenue share of 43% in 2022.

Introduction

Downstream processing includes sequence of unit operations utilized to separate, disinfect, and distillate the product. This process regularly defines the economic viability of the process. This process include the succession of operations needed to take biological materials including tissue culture fluid, cells, and plant tissues, and derive homogeneous and clean protein product out of them. Biopharmaceutical downstream processing involves retrieval and decontamination of a drug substance out of natural sources like bacterial or animal cells. This process is appropriate in protein processes or mAb also for production of polysaccharides, oligonucleotides, and numerous vaccines.

Maximum biopharmaceuticals are therapeutic proteins those are formed in living cells via recombinant engineering, and then sanitized from their culture cells or media with the help ofcultured protein purification methods in a multiple stage downstream process. The effectiveness with which cells yield target proteins through the bio manufacturing process has enhanced fundamentally within the last few years, forming pressure on the downstream operations. There are many areas in downstream processes that have to be upgraded and capitalized in such as new chromatography resins that expand the complete purification capacity.

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Growth Factors

Escalation in R&D expenditure by biopharmaceutical establishments and uptake in demand for biopharmaceuticals greatly fuels the growth of downstream processing market across the globe. Furthermore, improved demands for novel solutions, cost saving, process optimization, and progress in usage of techniques like centrifuge to distinct biological particles from suspension are some other influences areprompting the growth of downstream processing market. In contrast, requirement for experienced specialists and high price of instruments needed for processing are curtailing the market growth.

A stable upsurge in the recombinant produces and sale for drug quality has compelled the acceptance of downstream processing across the world. The intensification in the perception of large molecules and the biologics is further awaited to motivate the implementation of downstream methodologies.

Regional Snapshots

North America region emerged as leading marketplace for downstream processing and gathered major chunk of the revenue generated by market in 2019. This is attributed to motivating government funding for the preferment of bioprocess technologies, a substantial escalation in medical outlay, and the existence of vigorous healthcare infrastructure. North America has further perceived foremost cooperative activities and the governance of some of the healthcare giants those are expansively making spending in the R&D of vaccines and biopharmaceuticals.

Incessant technical progressions in the biotechnology sector of the U.S. have led to a substantial upsurge in the trade of recombinant products. It is predicted that there would be a 10-fold upsurge in trades during years to come. Hence, constant invention in the bioprocessing and biotechnology area is anticipated to offer growth boulevardsin the U.S. downstream processing marketplace.

Report Highlights

Asia Pacific is estimated record firmest growth rate during the prediction period in the downstream processing sector. Nations such as India, China, Japan, and South Korea, are likely to motivate the sale for downstream processing products during years to come
In 2019, chromatography segment conquered the global downstream processing market revenue with the maximum share of the total market.
In 2019, North America acquired maximum market share in downstream processing sector and is projected to maintain this strong hold throughout the valuation period
The antibiotic production segment appeared as most dominating application in 2019
Growth in of downstream market in evolving countries is powered by substantial funds by vital market performers, cumulative government funding, emergent R&D infrastructure, and mounting proficiency and academic brilliance

Key Players & Strategies

Rapid progresses in escalating upstream procedures for biologics production have left downstream processes as a blockage in the production scheme. Biomanufacturers are chasing unceasing downstream process improvement in order to surge flexibility and competence, diminish cost of goods, and advance product uniformity and superiority.

In line with these efforts, GE declared a Protein A chromatography resin named, MabSelectPrismA, that has augmented alkaline stability and dynamic binding capability. This proposes likelihood to recover the productivity of recent chromatography systems and columns deprived ofpricey capital outlays, constructing more competent practice of the prevailing manufacturing impression. With the help of these supplementary process design choices and tools downstream operations can retain pace with upstream activities and upsurge total productivity in mAb processing.

Corporations that are estimated to endure dynamic in the development of downstream processing marketplace are General Electric Company, Thermo Fisher Scientific, Inc., Danaher Corporation, Merck & Co Inc., Corning Incorporated, 3M Company, Repligen Corporation, Eppendorf AG, and Lonza Group Ltd. These companies are indulging in strategic partnerships, and merger arrangements with other performers to uphold a competitive advantage in the downstream processing marketplace. For example, Sartorius Stedim Biotech partnered with Novasep, in March 2019. They will together improve innovative systems for membrane chromatography and single-use bioprocessing. Such strategic are anticipated to augment the accessibility of cutting-edge products for downstream processing and chromatography, which in turn, is estimated to benefit the progression of downstream processing market.

Downstream Processing Market Players

BoehringerIngelheim
Danaher Corporation
Sartorius Stedium Biotech S.A
GE Healthcare
Merck Millipore
Eppendorf AG
3M Company
Thermo Fisher Scientific Inc
Finesse Solutions Inc
Lonza Group

Segments Covered in the Report

By Product

Centrifuges
Dryers
Chromatography Systems
Filters
Evaporators
Others

By Application

Antibodies Production
Antibiotic Production
Hormone Production
Enzyme Production
Vaccine Production

By Technique

Purification by Chromatography
Solid-liquid Separation
- Centrifugation
- Filtration
Cell Disruption
Concentration
Formulation

By Regional Outlook

North America
- U.S.
- Canada
Europe
- U.K.
- Germany
- France
Asia Pacific
- China
- India
- Japan
- South Korea
Middle East & Africa
Latin America

Table of Content

Chapter 1. Introduction

1.1. Research Objective
1.2. Scope of the Study
1.3. Definition

Chapter 2. Research Methodology

2.1. Research Approach
2.2. Data Sources
2.3. Assumptions & Limitations

Chapter 3. Executive Summary

3.1. Market Snapshot

Chapter 4. Market Variables and Scope

4.1. Introduction
4.2. Market Classification and Scope
4.3. Industry Value Chain Analysis
4.3.1. Raw Material Procurement Analysis
4.3.2. Sales and Distribution Channel Analysis
4.3.3. Downstream Buyer Analysis

Chapter 5. Market Dynamics Analysis and Trends

5.1. Market Dynamics
5.1.1. Market Drivers
5.1.2. Market Restraints
5.1.3. Market Opportunities
5.2. Porter’s Five Forces Analysis
5.2.1. Bargaining power of suppliers
5.2.2. Bargaining power of buyers
5.2.3. Threat of substitute
5.2.4. Threat of new entrants
5.2.5. Degree of competition

Chapter 6. Competitive Landscape

6.1.1. Company Market Share/Positioning Analysis
6.1.2. Key Strategies Adopted by Players
6.1.3. Vendor Landscape
6.1.3.1. List of Suppliers
6.1.3.2. List of Buyers

Chapter 7. Global Downstream Processing Market, By Product

7.1. Downstream Processing Market, by Product Type, 2023-2032
7.1.1. Centrifuges
7.1.1.1. Market Revenue and Forecast (2021-2032)
7.1.2. Dryers
7.1.2.1. Market Revenue and Forecast (2021-2032)
7.1.3. Chromatography Systems
7.1.3.1. Market Revenue and Forecast (2021-2032)
7.1.4. Filters
7.1.4.1. Market Revenue and Forecast (2021-2032)
7.1.5. Evaporators
7.1.5.1. Market Revenue and Forecast (2021-2032)
7.1.6. Others
7.1.6.1. Market Revenue and Forecast (2021-2032)

Chapter 8. Global Downstream Processing Market, By Application

8.1. Downstream Processing Market, by Application, 2023-2032
8.1.1. Antibodies Production
8.1.1.1. Market Revenue and Forecast (2021-2032)
8.1.2. Antibiotic Production
8.1.2.1. Market Revenue and Forecast (2021-2032)
8.1.3. Hormone Production
8.1.3.1. Market Revenue and Forecast (2021-2032)
8.1.4. Enzyme Production
8.1.4.1. Market Revenue and Forecast (2021-2032)
8.1.5. Vaccine Production
8.1.5.1. Market Revenue and Forecast (2021-2032)

Chapter 9. Global Downstream Processing Market, By Technology

9.1. Downstream Processing Market, by Technology, 2023-2032
9.1.1. Purification by Chromatography
9.1.1.1. Market Revenue and Forecast (2021-2032)
9.1.2. Solid-liquid Separation
9.1.2.1. Market Revenue and Forecast (2021-2032)
9.1.3. Cell Disruption
9.1.3.1. Market Revenue and Forecast (2021-2032)
9.1.4. Concentration
9.1.4.1. Market Revenue and Forecast (2021-2032)
9.1.5. Formulation
9.1.5.1. Market Revenue and Forecast (2021-2032)

Chapter 10. Global Downstream Processing Market, Regional Estimates and Trend Forecast

10.1. North America
10.1.1. Market Revenue and Forecast, by Product (2021-2032)
10.1.2. Market Revenue and Forecast, by Application (2021-2032)
10.1.3. Market Revenue and Forecast, by Technology (2021-2032)
10.1.4. U.S.
10.1.4.1. Market Revenue and Forecast, by Product (2021-2032)
10.1.4.2. Market Revenue and Forecast, by Application (2021-2032)
10.1.4.3. Market Revenue and Forecast, by Technology (2021-2032)
10.1.5. Rest of North America
10.1.5.1. Market Revenue and Forecast, by Product (2021-2032)
10.1.5.2. Market Revenue and Forecast, by Application (2021-2032)
10.1.5.3. Market Revenue and Forecast, by Technology (2021-2032)
10.2. Europe
10.2.1. Market Revenue and Forecast, by Product (2021-2032)
10.2.2. Market Revenue and Forecast, by Application (2021-2032)
10.2.3. Market Revenue and Forecast, by Technology (2021-2032)
10.2.4. UK
10.2.4.1. Market Revenue and Forecast, by Product (2021-2032)
10.2.4.2. Market Revenue and Forecast, by Application (2021-2032)
10.2.4.3. Market Revenue and Forecast, by Technology (2021-2032)
10.2.5. Germany
10.2.5.1. Market Revenue and Forecast, by Product (2021-2032)
10.2.5.2. Market Revenue and Forecast, by Application (2021-2032)
10.2.5.3. Market Revenue and Forecast, by Technology (2021-2032)
10.2.6. France
10.2.6.1. Market Revenue and Forecast, by Product (2021-2032)
10.2.6.2. Market Revenue and Forecast, by Application (2021-2032)
10.2.6.3. Market Revenue and Forecast, by Technology (2021-2032)
10.2.7. Rest of Europe
10.2.7.1. Market Revenue and Forecast, by Product (2021-2032)
10.2.7.2. Market Revenue and Forecast, by Application (2021-2032)
10.2.7.3. Market Revenue and Forecast, by Technology (2021-2032)
10.3. APAC
10.3.1. Market Revenue and Forecast, by Product (2021-2032)
10.3.2. Market Revenue and Forecast, by Application (2021-2032)
10.3.3. Market Revenue and Forecast, by Technology (2021-2032)
10.3.4. India
10.3.4.1. Market Revenue and Forecast, by Product (2021-2032)
10.3.4.2. Market Revenue and Forecast, by Application (2021-2032)
10.3.4.3. Market Revenue and Forecast, by Technology (2021-2032)
10.3.5. China
10.3.5.1. Market Revenue and Forecast, by Product (2021-2032)
10.3.5.2. Market Revenue and Forecast, by Application (2021-2032)
10.3.5.3. Market Revenue and Forecast, by Technology (2021-2032)
10.3.6. Japan
10.3.6.1. Market Revenue and Forecast, by Product (2021-2032)
10.3.6.2. Market Revenue and Forecast, by Application (2021-2032)
10.3.6.3. Market Revenue and Forecast, by Technology (2021-2032)
10.3.7. Rest of APAC
10.3.7.1. Market Revenue and Forecast, by Product (2021-2032)
10.3.7.2. Market Revenue and Forecast, by Application (2021-2032)
10.3.7.3. Market Revenue and Forecast, by Technology (2021-2032)
10.4. MEA
10.4.1. Market Revenue and Forecast, by Product (2021-2032)
10.4.2. Market Revenue and Forecast, by Application (2021-2032)
10.4.3. Market Revenue and Forecast, by Technology (2021-2032)
10.4.4. GCC
10.4.4.1. Market Revenue and Forecast, by Product (2021-2032)
10.4.4.2. Market Revenue and Forecast, by Application (2021-2032)
10.4.4.3. Market Revenue and Forecast, by Technology (2021-2032)
10.4.5. North Africa
10.4.5.1. Market Revenue and Forecast, by Product (2021-2032)
10.4.5.2. Market Revenue and Forecast, by Application (2021-2032)
10.4.5.3. Market Revenue and Forecast, by Technology (2021-2032)
10.4.6. South Africa
10.4.6.1. Market Revenue and Forecast, by Product (2021-2032)
10.4.6.2. Market Revenue and Forecast, by Application (2021-2032)
10.4.6.3. Market Revenue and Forecast, by Technology (2021-2032)
10.4.7. Rest of MEA
10.4.7.1. Market Revenue and Forecast, by Product (2021-2032)
10.4.7.2. Market Revenue and Forecast, by Application (2021-2032)
10.4.7.3. Market Revenue and Forecast, by Technology (2021-2032)
10.5. Latin America
10.5.1. Market Revenue and Forecast, by Product (2021-2032)
10.5.2. Market Revenue and Forecast, by Application (2021-2032)
10.5.3. Market Revenue and Forecast, by Technology (2021-2032)
10.5.4. Brazil
10.5.4.1. Market Revenue and Forecast, by Product (2021-2032)
10.5.4.2. Market Revenue and Forecast, by Application (2021-2032)
10.5.4.3. Market Revenue and Forecast, by Technology (2021-2032)
10.5.5. Rest of LATAM
10.5.5.1. Market Revenue and Forecast, by Product (2021-2032)
10.5.5.2. Market Revenue and Forecast, by Application (2021-2032)
10.5.5.3. Market Revenue and Forecast, by Technology (2021-2032)

Chapter 11. Company Profiles

11.1. BoehringerIngelheim
11.1.1. Company Overview
11.1.2. Product Offerings
11.1.3. Financial Performance
11.1.4. Recent Initiatives
11.2. Danaher Corporation
11.2.1. Company Overview
11.2.2. Product Offerings
11.2.3. Financial Performance
11.2.4. Recent Initiatives
11.3. Sartorius Stedium Biotech S.A
11.3.1. Company Overview
11.3.2. Product Offerings
11.3.3. Financial Performance
11.3.4. Recent Initiatives
11.4. GE Healthcare
11.4.1. Company Overview
11.4.2. Product Offerings
11.4.3. Financial Performance
11.4.4. Recent Initiatives
11.5. Merck Millipore
11.5.1. Company Overview
11.5.2. Product Offerings
11.5.3. Financial Performance
11.5.4. Recent Initiatives
11.6. Eppendorf AG
11.6.1. Company Overview
11.6.2. Product Offerings
11.6.3. Financial Performance
11.6.4. Recent Initiatives
11.7. 3M Company
11.7.1. Company Overview
11.7.2. Product Offerings
11.7.3. Financial Performance
11.7.4. Recent Initiatives
11.8. Thermo Fisher Scientific Inc
11.8.1. Company Overview
11.8.2. Product Offerings
11.8.3. Financial Performance
11.8.4. Recent Initiatives
11.9. Finesse Solutions Inc
11.9.1. Company Overview
11.9.2. Product Offerings
11.9.3. Financial Performance
11.9.4. Recent Initiatives
11.10. Lonza Group
11.10.1. Company Overview
11.10.2. Product Offerings
11.10.3. Financial Performance
11.10.4. Recent Initiatives