Protein Expression Market Size To Reach Around USD 12.27 Bn By 2034

The global protein expression market has experienced strong growth, driven by the increasing demand for biologics, advanced therapeutics, and R&D innovations. Valued at USD 4.68 billion in 2024, the market is projected to reach USD 12.27 billion by 2034, growing at a robust CAGR of 10.45% from 2025 to 2034. North America currently leads the market, with the U.S. protein expression market estimated at USD 1.37 billion in 2023.

Read Also: Clinical Trials Market

Key Takeaways

• Prokaryotic expression systems held 43.70% market share in 2024.

• Eukaryotic expression systems expected to grow at CAGR of 9.10%, driven by demand for cell-based therapies.

• Reagents dominate the product type segment with a 48.50% share.

• Services segment projected to grow at a CAGR of 9.40%, fueled by outsourcing trends.

• Therapeutic development application accounted for 41.60% share and is expected to grow at CAGR of 8.90%.

• Pharmaceutical & biotechnology companies are the largest end-users with 45.20% share.

• Stable expression method led with 33.50% share, while cell-free protein synthesis is fastest-growing at CAGR of 10.10%.

• North America captured more than 41% revenue share in 2023, followed by Europe and Asia Pacific.

Market Overview

Protein expression is the process through which a cell synthesizes proteins based on genetic instructions. It involves:

1. Transcription – DNA is transcribed into messenger RNA (mRNA).

2. Translation – mRNA is translated into a specific protein sequence.

Applications of protein expression include:

• Recombinant protein production

• Drug discovery and development

• Therapeutics and vaccines

• Research in proteomics and genomics

Market Scope

Growth Factors

1. Rising Demand for Protein-Based Therapeutics

   • Personalized medicine and biologics are driving growth.

   • Collaborations like Merck and Orna Therapeutics’ $150M investment in RNA technology boost market expansion.

2. Technological Advancements

   • Cell-free protein synthesis enables rapid prototyping and production of difficult-to-express proteins.

   • Microfluidics technology allows precise protein expression and screening.

3. Biopharmaceutical Investments

   • Companies invest heavily in recombinant protein production and cell-based systems.

   • Strategic collaborations between industry and academia accelerate innovation.

4. Automation and AI Integration

   • AI and automation streamline workflows, reduce errors, and accelerate research timelines.

Expression System Insights

• Prokaryotic Systems: Most widely used due to simplicity and cost-effectiveness.

• Eukaryotic Systems: Fastest-growing, supporting cell-based therapies, mammalian, yeast, insect, and plant systems.

Product Type Insights

• Reagents: Essential for protein folding and conformation, dominating 48.50% of the market.

• Services: Highest CAGR of 9.40%, including custom protein expression, cell line development, and CRAMS.

Application Insights

• Therapeutic Development: Leading segment, offering specificity, low side effects, and effectiveness.

• Monoclonal antibodies, vaccines, enzymes, and hormones drive protein expression applications across therapeutics and industrial use.

End-Use Insights

• Pharmaceutical & Biotech Companies: Largest users, utilizing cultured cells for therapeutics.

• CMOs and CDMOs: Fastest-growing, driven by biologics and biosimilar production.

Expression Method Insights

• Stable Expression: Dominates with 33.50% market share.

• Cell-Free Protein Synthesis: Fastest-growing at 10.10% CAGR, enabling targeted and precision therapeutics.

Market Drivers

• Rising interest in biologics to treat cancer, autoimmune diseases, and chronic conditions.

• Strategic collaborations and funding for protein therapeutics development.

• Emerging technologies like microfluidics and cell-free systems.

Market Challenges

• Post-translational modifications and purification complexities.

• Structural intricacies of proteins can reduce yield and stability.

Opportunities

• Microfluidics adoption enables precise control of protein synthesis.

• Automation and AI improve efficiency in R&D and production.

• Personalized medicine expands demand for targeted protein therapeutics.

Key Market Players

• Agilent Technologies Inc.

• Bio-Rad Technologies

• Thermo Fisher Scientific Inc.

• Merck KGaA

• Takara Bio Inc.

• New England Biolabs Inc.

• Oxford Expression Technologies Ltd

• Promega Corporation

• Qiagen NV

• Sigma-Aldrich Corporation

• About
• Latest Posts

ritika jankar

Latest posts by ritika jankar (see all)

• Antibody Drug Conjugates Market Size to Hit USD 31.96 Bn by 2034 - October 8, 2025
• Protein Expression Market Size To Reach Around USD 12.27 Bn By 2034 - October 8, 2025
• Clinical Trials Market Size to Reach USD 149.58 Billion by 2034 - October 8, 2025